Minocycline-EDTA Lock Solution Prevents Catheter-Related Bacteremia in Hemodialysis

1. Rodrigo Peixoto Campos*§, 
 
2. Marcelo Mazza do Nascimento†,
 
3. Domingos Candiota Chula‡ and 
4. Miguel Carlos Riella*†

1. ^*Center for Health and Biological Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil;
2. ^†Division of Nephrology, Hospital Universitário Evangélico de Curitiba, Curitiba, Brazil;
3. ^‡Clínica de Doenças Renais do Novo Mundo, Curitiba, Brazil;
4. ^§Division of Nephrology, Hospital São Lucas, Campo Largo, Brazil

JASN Aug 18, 2011 ASN.2010121306;published ahead of print August 18, 2011

Abstract:

There is growing concern about the development of antibacterial resistance with the use of antibiotics in catheter lock solutions. The use of an antibiotic that is not usually used to treat other serious infections may be an alternative that may reduce the clinical impact should resistance develop. We conducted a randomized controlled trial to compare a solution of minocycline and EDTA with the conventional unfractionated heparin for the prevention of catheter-related bacteremia in hemodialysis patients during a period of 90 d. The study included 204 incident catheters (27.8% tunneled); 14 catheters were excluded because of early dysfunction and 3 because of protocol violations. We observed catheter-related bacteremia in 19 patients in the heparin group (4.3 per 1000 catheter-days) and in 5 patients in the minocycline-EDTA group (1.1 per 1000 catheter-days; P = 0.005). We did not detect a significant difference in the rate of catheter removal for dysfunction. Catheter-related bacteremia-free survival was significantly higher in the minocycline-EDTA group than in the heparin group (P = 0.005). In conclusion, a minocycline-EDTA catheter lock solution is effective in the prevention of catheter-related bacteremia in hemodialysis patients